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Jtp 2942

NMR下載 COA and HPLC MSDS下載
names：
(S)-1-(((S)-1-methyl-3-oxocyclopentane-1-carbonyl)-L-histidyl)pyrrolidine-2-carboxamide
CAS號：
148152-77-6
MDL Number：
MF(分子式)： C18H25N5O4 MW(分子量)： 375.42
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Jtp 2942
英文別名	Jtp 2942; Jtp-2942; Jtp2942;
CAS號	148152-77-6
Inchi	InChI=1S/C18H25N5O4/c1-18(5-4-12(24)8-18)17(27)22-13(7-11-9-20-10-21-11)16(26)23-6-2-3-14(23)15(19)25/h9-10,13-14H,2-8H2,1H3,(H2,19,25)(H,20,21)(H,22,27)/t13-,14-,18-/m0/s1
InchiKey	QATMSFATAIOXJC-DEYYWGMASA-N
分子式 Formula	C18H25N5O4
分子量 Molecular Weight	375.42
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Jtp 2942(CAS:148152-77-6):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Jtp 2942 is a novel thyrotropin-releasing hormone analogue.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Ikeda K, Iwasaki Y, Kinoshita M. JTP-2942, a novel thyrotropin-releasing hormone analogue, protects against spinal motor neuron degeneration in the wobbler mouse. Neurosci Lett. 1998 Jun 26;250(1):9-12. PubMed PMID: 9696053.

[2]Matsushita M, Yonemori F, Hamada A, Toide K, Iwata K. Effect of JTP-2942, a novel thyrotropin-releasing hormone analogue, on pentobarbital-induced anesthesia in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):177-82. PubMed PMID: 7781687.

[3] Katsumata T, Katayama Y, Yonemori H, Muramatsu H, Otori T, Nishiyama Y, Yamada H, Nakamura H, Terashi A. Delayed administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, improves cerebral blood flow and metabolism in rat postischaemic brain. Clin Exp Pharmacol Physiol. 2001 Jan-Feb;28(1-2):48-54. PubMed PMID: 11153536.

[4] Urayama A, Yamada S, Deguchi Y, Kimura R, Maeda Y, Kobayashi T. Brain receptor binding characteristics and pharmacokinetics of JTP-2942, a novel thyrotropin-releasing hormone (TRH) analogue. Life Sci. 1999;65(22):2407-15. PubMed PMID: 10597895.

[5] Katsumata T, Katayama Y, Ootori T, Muramatsu H, Nishiyama Y, Nakamura H, Seta T, Terashi A. Effect of long-term administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, on neurological outcome, local cerebral blood flow and glucose utilization in a rat focal cerebral ischemia. Brain Res. 2001 May 18;901(1-2):62-70. PubMed PMID: 11368951.

6: Toide K, Shinoda M, Takase M, Iwata K, Yoshida H. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. Eur J Pharmacol. 1993 Mar 16;233(1):21-8. PubMed PMID: 8472746.7: Yonemori F, Yamaguchi T, Nakayama H, Narita K, Hojo S, Tamura A. Effect of JTP-2942, a novel thyrotropin-releasing hormone analog, on motor deficits after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2000 Jan;20(1):74-81. PubMed PMID: 10616795.8: Matsushita M, Yonemori F, Ohta A, Iwata K. Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia. Arzneimittelforschung. 1995 Jun;45(6):708-11. PubMed PMID: 7646576.9: Matsushita M, Yonemori F, Furukawa N, Ohta A, Toide K, Uchida I, Iwata K. Effects of the novel thyrotropin-releasing hormone analogue Na -((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L-prol ina mide monohydrate on the central nervous system in mice and rats. Arzneimittelforschung. 1993 Aug;43(8):813-7. PubMed PMID: 8216433.

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