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Lifarizine methanesulfonate

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names：
1-benzhydryl-4-((5-methyl-2-(p-tolyl)-1H-imidazol-4-yl)methyl)piperazine methanesulfonate
CAS號：
130565-83-2
MDL Number：
MF(分子式)： C30H36N4O3S MW(分子量)： 532.7
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Lifarizine methanesulfonate
英文別名	Lifarizine methanesulfonate;
CAS號	130565-83-2
Inchi	InChI=1S/C29H32N4.CH4O3S/c1-22-13-15-26(16-14-22)29-30-23(2)27(31-29)21-32-17-19-33(20-18-32)28(24-9-5-3-6-10-24)25-11-7-4-8-12-25;1-5(2,3)4/h3-16,28H,17-21H2,1-2H3,(H,30,31);1H3,(H,2,3,4)
InchiKey	CGPIUYHUELMXMK-UHFFFAOYSA-N
分子式 Formula	C30H36N4O3S
分子量 Molecular Weight	532.7
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Lifarizine methanesulfonate(CAS:130565-83-2):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Lifarizine methanesulfonate is a sodium-calcium channel modulator that reduces ischemic brain damage.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Brown NA, Kemp JA, Seabrook GR. Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine. Br J Pharmacol. 1994 Oct;113(2):600-6. PubMed PMID: 7834213; PubMed Central PMCID: PMC1510106.

[2]Budd DC, May GR, Nicholls DG, McCormack JG. Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones. Br J Pharmacol. 1996 May;118(1):162-6. PubMed PMID: 8733590; PubMed Central PMCID: PMC1909495.

[3] MacKinnon AC, Wyatt KM, McGivern JG, Sheridan RD, Brown CM. [3H]-lifarizine, a high affinity probe for inactivated sodium channels. Br J Pharmacol. 1995 Jul;115(6):1103-9. PubMed PMID: 7582509; PubMed Central PMCID: PMC1908993.

[4] McBean DE, Winters V, Wilson AD, Oswald CB, Alps BJ, Armstrong JM. Neuroprotective efficacy of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion. Br J Pharmacol. 1995 Dec;116(8):3093-8. PubMed PMID: 8719782; PubMed Central PMCID: PMC1909165.

[5] May GR, Rowand WS, McCormack JG, Sheridan RD. Neuroprotective profile of lifarizine (RS-87476) in rat cerebrocortical neurones in culture. Br J Pharmacol. 1995 Apr;114(7):1365-70. PubMed PMID: 7606340; PubMed Central PMCID: PMC1510289.

6: McGivern JG, Patmore L, Sheridan RD. Actions of the novel neuroprotective agent, lifarizine (RS-87476), on voltage-dependent sodium currents in the neuroblastoma cell line, N1E-115. Br J Pharmacol. 1995 Apr;114(8):1738-44. PubMed PMID: 7599943; PubMed Central PMCID: PMC1510400.7: Alps BJ, Calder C, Wilson AD, McBean DE, Armstrong JM. Reduction by lifarizine of the neuronal damage induced by cerebral ischaemia in rodents. Br J Pharmacol. 1995 Aug;115(8):1439-46. PubMed PMID: 8564203; PubMed Central PMCID: PMC1908890.8: Brown CM, Calder C, Linton C, Small C, Kenny BA, Spedding M, Patmore L. Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia. Br J Pharmacol. 1995 Aug;115(8):1425-32. PubMed PMID: 8564201; PubMed Central PMCID: PMC1908884.9: Sheridan RD. Selectivity of the neuroprotective agent lifarizine. Trends Pharmacol Sci. 1995 Sep;16(9):292. PubMed PMID: 7482992.10: Brown CM, Calder C, Alps BJ, Spedding M. The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil. Br J Pharmacol. 1993 May;109(1):175-7. PubMed PMID: 8388296; PubMed Central PMCID: PMC2175597.1

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