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Ludartin

NMR下載 COA and HPLC MSDS下載
names：
Oxireno(2,3)azuleno(4,5-b)furan-2(3H)-one, 3a,4,5,7,7a,8a,8b,8c-octahydro-6,8a-dimethyl-3-methylene-, (3aS,7aR,8aS,8bS,8cS)-
CAS號：
36149-87-8
MDL Number：
MF(分子式)： C15H18O3 MW(分子量)： 246.306
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Ludartin
英文別名	Ludartin
CAS號	36149-87-8
Inchi	InChI=1S/C15H18O3/c1-7-4-5-9-8(2)14(16)17-13(9)12-10(7)6-11-15(12,3)18-11/h9,11-13H,2,4-6H2,1,3H3/t9-,11+,12-,13-,15+/m0/s1
InchiKey	QXJYIGSXUBOSID-JZEMPJKHSA-N
分子式 Formula	C15H18O3
分子量 Molecular Weight	246.306
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Ludartin(CAS:36149-87-8):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Ludartin is a TRPA1 channel activator that has been found to produce anticancer effects by inducing DNA damage and a reduction of mitochondrial membrane potential.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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備注

[1]Lone SH, Bhat KA, Majeed R, Hamid A, Khuroo MA. Click chemistry inspired facile synthesis and bioevaluation of novel triazolyl analogs of Ludartin. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1047-5[1]doi: 10.1016/j.bmcl.2014.01.018. Epub 2014 Jan 15. PubMed PMID: 24484897.

[2]Lone SH, Bhat KA, Shakeel-u-Rehman, Majeed R, Hamid A, Khuroo MA. Synthesis and biological evaluation of amino analogs of Ludartin: potent and selective cytotoxic agents. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4931-4. doi: 10.1016/j.bmcl.2013.06.068. Epub 2013 Jul 4. PubMed PMID: 23886685.

[3] Zeng YT, Jiang JM, Lao HY, Guo JW, Lun YN, Yang M. Antitumor and apoptotic activities of the chemical constituents from the ethyl acetate extract of Artemisia indica. Mol Med Rep. 2015 Mar;11(3):2234-40. doi: 10.3892/mmr.2014.3012. Epub 2014 Nov 27. PubMed PMID: 25434991.

[4] Lone SH, Bhat KA, Naseer S, Rather RA, Khuroo MA, Tasduq SA. Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Artemisia amygdalina Decne. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 1;940:135-41. doi: 10.1016/j.jchromb.2013.09.027. Epub 2013 Sep 27. PubMed PMID: 24148842.

[5] Gil RR, Gayathri C, Tsarevsky NV, Matyjaszewski K. Stretched poly(methyl methacrylate) gel aligns small organic molecules in chloroform. stereochemical analysis and diastereotopic proton NMR assignment in ludartin using residual dipolar couplings and 3J coupling constant analysis. J Org Chem. 2008 Feb 1;73(3):840-8. doi: 10.1021/jo701871g. Epub 2008 Jan 5. PubMed PMID: 18177050.

6: Giordano OS, Guerreiro E, Pestchanker MJ, Guzman J, Pastor D, Guardia T. The gastric cytoprotective effect of several sesquiterpene lactones. J Nat Prod. 1990 Jul-Aug;53(4):803-9. PubMed PMID: 2095374.7: Zhang SL, Li BL, Li W, Lu M, Ni LY, Ma HL, Meng QG. The Effects of Ludartin on Cell Proliferation, Cell Migration, Cell Cycle Arrest and Apoptosis Are Associated with Upregulation of p21WAF1 in Saos-2 Osteosarcoma Cells In Vitro. Med Sci Monit. 2018 Jul 16;2

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