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Restricticin

NMR下載 COA and HPLC MSDS下載
names：
(2R,3S,4R,5R)-2-((2E,4E,6E)-deca-2,4,6-trien-2-yl)-4-methoxy-5-methyltetrahydro-2H-pyran-3-yl glycinate
CAS號：
135357-96-9
MDL Number：
MF(分子式)： C19H31NO4 MW(分子量)： 337.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	(2R,3S,4R,5R)-2-((2E,4E,6E)-deca-2,4,6-trien-2-yl)-4-methoxy-5-methyltetrahydro-2H-pyran-3-yl glycinate
英文別名	Restricticin; Ro 09-1470; Ro-09-1470; Ro09-1470;
CAS號	135357-96-9
Inchi	InChI=1S/C19H31NO4/c1-5-6-7-8-9-10-11-14(2)18-19(24-16(21)12-20)17(22-4)15(3)13-23-18/h7-11,15,17-19H,5-6,12-13,20H2,1-4H3/b8-7+,10-9+,14-11+/t15-,17-,18-,19+/m1/s1
InchiKey	FIFAQBUMNRZWOQ-OVBFOOSGSA-N
分子式 Formula	C19H31NO4
分子量 Molecular Weight	337.46
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Restricticin(CAS:135357-96-9):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Restricticin is a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Schwartz RE, Dufresne C, Flor JE, Kempf AJ, Wilson KE, Lam T, Onishi J, Milligan J, Fromtling RA, Abruzzo GK, et al. Restricticin, a novel glycine-containing antifungal agent. J Antibiot (Tokyo). 1991 May;44(5):463-7[1]PubMed PMID: 2061189.

[2]VanMiddlesworth F, Milligan J, Bartizal K, Dufresne C, Onishi J, Abruzzo G, Patchett A, Wilson K. Carbazate as a glycine bioisostere in restricticin. J Antibiot (Tokyo). 1996 Mar;49(3):329-31. PubMed PMID: 8626254.

[3] Tsukuda T, Watanabe M, Ontsuka H, Hattori K, Shirai M, Shimma N. Synthesis of novel antifungal agents (2). Bioorg Med Chem Lett. 1998 Jul 21;8(14):1825-8. PubMed PMID: 9873441.

[4] Tsukuda T, Shiratori Y, Watanabe M, Ontsuka H, Hattori K, Shirai M, Shimma N. Modeling, synthesis and biological activity of novel antifungal agents (1). Bioorg Med Chem Lett. 1998 Jul 21;8(14):1819-24. PubMed PMID: 9873440.

[5] Barrett AG, Bennett AJ, Menzer S, Smith ML, White AJ, Williams DJ. Applications of Crotonyldiisopinocampheylboranes in Synthesis: Total Synthesis of Restrictinol. J Org Chem. 1999 Jan 8;64(1):162-171. PubMed PMID: 11674099.

6: Aoki Y, Yoshihara F, Kondoh M, Nakamura Y, Nakayama N, Arisawa M. Ro 09-1470 is a selective inhibitor of P-450 lanosterol C-14 demethylase of fungi. Antimicrob Agents Chemother. 1993 Dec;37(12):2662-7. PubMed PMID: 8109933; PubMed Central PMCID: PMC192771.7: Aoki Y, Yamazaki T, Kondoh M, Sudoh Y, Nakayama N, Sekine Y, Shimada H, Arisawa M. A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. II. Mode of action. J Antibiot (Tokyo). 1992 Feb;45(2):160-70. PubMed PMID: 1556007.8: Matsukuma S, Ohtsuka T, Kotaki H, Shirai H, Sano T, Watanabe K, Nakayama N, Itezono Y, Fujiu M, Shimma N, et al. A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. I. Taxonomy, fermentation, isolation and structural elucidation. J Antibiot (Tokyo). 1992 Feb;45(2):151-9. PubMed PMID: 1556006.

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