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Xestoquinone

NMR下載 COA and HPLC MSDS下載
names：
1H-Benzo(6,7)phenanthro(10,1-bc)furan-6,8,11(12bH)-trione, 2,3-dihydro-12b-methyl-, (S)-
CAS號：
97743-96-9
MDL Number：
MF(分子式)： C20H14O4 MW(分子量)： 318.328
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	1H-Benzo(6,7)phenanthro(10,1-bc)furan-6,8,11(12bH)-trione, 2,3-dihydro-12b-methyl-, (S)-
英文別名	Xestoquinone;
CAS號	97743-96-9
Inchi	InChI=1S/C20H14O4/c1-20-6-2-3-10-9-24-19(17(10)20)18(23)13-7-11-12(8-14(13)20)16(22)5-4-15(11)21/h4-5,7-9H,2-3,6H2,1H3/t20-/m0/s1
InchiKey	HDONDRKCXFRHQQ-FQEVSTJZSA-N
分子式 Formula	C20H14O4
分子量 Molecular Weight	318.328
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Xestoquinone(CAS:97743-96-9):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Xestoquinone is a biochemical.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Du L, Mahdi F, Datta S, Jekabsons MB, Zhou YD, Nagle DG. Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells. J Nat Prod. 2012 Sep 28;75(9):1553-9. Epub 2012 Aug 3[1]PubMed PMID: 22938093; PubMed Central PMCID: PMC3482980.

[2]Winder PL, Baker HL, Linley P, Guzmán EA, Pomponi SA, Diaz MC, Reed JK, Wright AE. Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima. Bioorg Med Chem. 2011 Nov 15;19(22):6599-603. doi: 10.1016/j.bmc.2011.09.026. Epub 2011 Sep 21. PubMed PMID: 22014756; PubMed Central PMCID: PMC3268459.

[3] Gademann K, Kobylinska J. Antimalarial natural products of marine and freshwater origin. Chem Rec. 2009;9(3):187-98. doi: 10.1002/tcr.200900001. Review. PubMed PMID: 19424997.

[4] Desoubzdanne D, Marcourt L, Raux R, Chevalley S, Dorin D, Doerig C, Valentin A, Ausseil F, Debitus C. Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge. J Nat Prod. 2008 Jul;71(7):1189-92. doi: 10.1021/np8000909. Epub 2008 May 31. PubMed PMID: 18512987.

[5] Laurent D, Jullian V, Parenty A, Knibiehler M, Dorin D, Schmitt S, Lozach O, Lebouvier N, Frostin M, Alby F, Maurel S, Doerig C, Meijer L, Sauvain M. Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp. Bioorg Med Chem. 2006 Jul 1;14(13):4477-82. Epub 2006 Mar 2. PubMed PMID: 16513357.

6: Nakamura M, Kakuda T, Qi J, Hirata M, Shintani T, Yoshioka Y, Okamoto T, Oba Y, Nakamura H, Ojika M. Novel relationship between the antifungal activity and cytotoxicity of marine-derived metabolite xestoquinone and its family. Biosci Biotechnol Biochem. 2005 Sep;69(9):1749-52. PubMed PMID: 16195594.7: Cao S, Foster C, Brisson M, Lazo JS, Kingston DG. Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp. Bioorg Med Chem. 2005 Feb 15;13(4):999-1003. PubMed PMID: 15670907.8: Nakamura M, Kakuda T, Oba Y, Ojika M, Nakamura H. Synthesis of biotinylated xestoquinone that retains inhibitory activity against Ca2+ ATPase of skeletal muscle myosin. Bioorg Med Chem. 2003 Jul 17;11(14):3077-82. PubMed PMID: 12818670.9: Fujiwara H, Matsunaga K, Saito M, Hagiya S, Furukawa K, Nakamura H, Ohizumi Y. Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells. Eur J Pharmacol. 2001 Feb 9;413(1):37-45. PubMed PMID: 11173061.10: Ito M, Hirata Y, Nakamura H, Ohizumi Y. Xestoquinone, isolated from sea sponge, causes Ca(2+) release through sulfhydryl modification from skeletal muscle sarcoplasmic reticulum. J Pharmacol Exp Ther. 1999 Dec;291(3):976-81. PubMed PMID: 10565813.1

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